ERG Antibody

Size : 50 µL Clone Number: Aliases: Avian erythroblastosis virus E-26 (v-ets) oncogene related antibody; D030036I24Rik antibody; Erg 3 antibody; Erg antibody; ERG/EWS fusion gene; included antibody; ERG/FUS fusion gene; included antibody; ERG/TMPSSR2 fusion gene; included antibody; ERG_HUMAN antibody; ERG1; included antibody; ERG2; included antibody; ets related antibody; ETS-related gene antibody; KCNH2 antibody; Oncogene ERG antibody; p55 antibody; TMPRSS2/ERG fusion antibody; transcriptional regulator ERG (transforming protein ERG) antibody; Transcriptional regulator ERG antibody; Transforming protein ERG antibody; v ets avian erythroblastosis virus E26 oncogene antibody; v ets avian erythroblastosis virus E26 oncogene related antibody; v ets erythroblastosis virus E26 oncogene homolog antibody; v ets erythroblastosis virus E26 oncogene like antibody; v ets erythroblastosis virus E26 oncogene like isoform 2 antibody; v-ets erythroblastosis virus E26 oncogene antibody; v-ets erythroblastosis virus E26 oncogene homolog (avian) antibody; V-ets erythroblastosis virus E26 oncogene like (Avian); isoform CRA_e antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: P11308 Immunogen: Fusion protein of Human ERG Host: Rabbit Reactivity: Human, Mouse Tested Applications: ELISA, WB, IHC; ELISA: 1: 2000-1: 5000, WB: 1: 500-1: 2000, IHC: 1: 50-1: 200 Background: This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. Clonality: Polyclonal Isotype: IgG Purification Method: Antigen affinity purification Conjugate: Non-conjugated Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: ERG Research Areas: Epigenetics and Nuclear Signaling;Cancer;Stem cells