KSR1 Antibody

Size : 50 µL Clone Number: Aliases: BKSR 1 antibody; BKSR1 antibody; dKsr antibody; EK 31 antibody; EK31 antibody; hb antibody; Kinase suppressor of Ras 1 antibody; Kinase suppressor of ras antibody; KSR 1 antibody; KSR antibody; KSR1 antibody; KSR1_HUMAN antibody; Positive Ras signaling mediator family member (86.4 kD) antibody; Positive Ras signaling mediator family member antibody; RSU 2 antibody; RSU2 antibody; SR 31 antibody; SR31 antibody; Suppressor of activated let 60 Ras SUR3 antibody; Suppressor of Ras1 31 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q8IVT5 Immunogen: Synthetic peptide of Human KSR1 Host: Rabbit Reactivity: Human, Mouse Tested Applications: ELISA, IHC; ELISA: 1: 2000-1: 5000, IHC: 1: 50-1: 200 Background: Several serine/threonine protein kinases have been implicated as intermediates in signal transduction pathways. These include ERK/MAP kinases, ribosomal S6 kinase (Rsk) and Raf-1. Raf-1 has intrinsic kinase activity towards serine/threonine residues and is widely expressed in many tissue types and cell lines. Raf-1 activation is dependent on the small molecular weight GTPase Ras, but the means by which this activation occurs is poorly understood. Two proteins putatively involved in this process are Ksr-1 and Tak1. Ksr-1 (kinase suppressor of Ras) is a novel Raf-related protein kinase whose function is required for Ras signal transduction. Whether Ksr-1 lies directly downstream of Ras or acts in a parallel pathway is not yet known. Tak1 (TGF -activated kinase) has been shown to participate in the activation of the MAP kinase family in response to TGF stimulation. Clonality: Polyclonal Isotype: IgG Purification Method: Antigen affinity purification Conjugate: Non-conjugated Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: KSR1 Research Areas: Signal transduction